Efektivitas Ekstrak Etanol Daun Bayam Merah sebagai Hepatoprotektor terhadap Kadar ALP Serum Mencit yang Diinduksi Isoniazid
ABSTRACT: Isoniazid (INH) is
metabolized become hidrazine that depleted glutation (GSH) in hepatocytes,
resulted imbalance oxidant and antioxidant along with increased of free
radicals, which can increase alkaline phosphatase (ALP). Ethanolic extract of
red spinach (Amaranthus tricolor L.) leaves contains antioxidant which can
donates the electron so free radical can be stabilized. The aim of this study
was to investigate the effect of ethanolic extract of red spinach leaves on ALP
levels of mice induced by INH and its effective dose. This research used 28
mices that divided into seven groups: K(N) was given normal saline, K(-) was
given INH 100 mg/kgBW, K1, K2, K3, K4 and K5 group which given INH 100 mg/kgBW
peroral and after 2 hours would be given ethanolic extract of red spinach
leaves in the dose 1,05 mg/20gBW, 2,1 mg/20gBW, 4,2 mg/20gBW, 8,4 mg/20gBW and
16,8 mg/20gBW for ten days. ALP serum was measured on the day 11th.The result
of average ALP levels were K(N) 41,36 U/L, K(-) 110,97 U/L, K1 79,26 U/L, K2
71,34 U/L, K3 66,51 U/L, K4 62,82 U/L and K5 47,21 U/L. In conclusion the
ethanolic extract of red spinach leaves could prevent the increasing of ALP
levels and the effective dose of the extract was 6,75 mg/20gBW.
Keywords: red spinach leaves,
ALP, INH
Penulis: Shinta Madyaning Wuri,
Aris Prasetyo, Elly Nurus Sakinah
Kode Jurnal: jpkesmasdd170103
