EFFEKTIVITAS INFUSA AKAR MANIS SEBAGAI ANTI TUKAK LAMBUNG TIKUS YANG DIINDUKSI ASETOSAL
Abstract: The use of
NSAID-class drugs such as acetosal is widely used by the community, which can
cause peptic ulcers. Gastric ulcers are damaged in the mucosal and sub mucosal
tissues. Indonesia is rich in traditional medicinal ingredients such as
liquorice that can serve as an ingredient of anti ulcers. The purpose of this
study is to determine the effect of the effectiveness of the extract of sweet
root as gastroprotektor. Design of laboratory experiment post test with
control. A total of 30 male Wistar strains of 2-3 months old, with 100-250 gram
weight divided into 6 groups, each group consisted of 5 randomly divided animal
animals, ie KI (sweet root) 5 mg / 200g BB), K.II (sweet root 10 mg/ 200g BB),
K.III (sweet root 15 mg / 200g BB), K. IV (sucralfat 72 mg / 200g BB), K. V
(acetosal 90 Mg / 200 g BB) and K.VI (without treatment). All treatments were
administered orally for seven days. Observations were macroscopic and
microscopic gastric mice. The results of the study: Group III had the greatest
gastroprotector compared with other groups as indicated by the number of
lesions, lesion area, damage score, number of mast cells and eosinophil cells
were lower than those given the assetosal group (p <0.05)
Keywords: Sweet Root, Gastroprotective
And Gastric Ulcers
Penulis: Joko Santoso
Kode Jurnal: jpkebidanandd170347
