Fakultas Kedokteran Universitas Jember
ABSTRACT: Malaria is one of
endemic disease in Indonesia that caused many deaths. Immune system plays
important rules in preventing malaria severity. Bangle has been proven as an
immunostimulant and could reduce parasitaemia in malaria infection. This study
aimed to determine the activity of n-hexane fraction of bangle methanolic
extract as complementary therapy of malaria. This study used 28 mice, divided
into one positive control group, one negative control group, and five treatment
groups. Bangle stimulation before induction was given to five treatment groups
with dose: 0,005625mg/grbw, 0,01125mg/grbw, 0,0225mg/grbw, 0,045mg/grbw, and
0,09mg/grbw for 14 days. Plasmodium berghei induction was given to all groups,
and then treatment groups were given ACT and bangle fraction, and positive
control group was given ACT without fraction for three days. Parasitaemia was
observed everyday, then plasmodium growth inhibition percentation was counted.
Bangle fraction stimulation gave lower parasitaemia at the begining and Pearson
correlation test showed strong positive correlation between dose of bangle
fraction and plasmodium growth inhibition percentation (p<0,01). We can
conclude that n-hexane fraction of bangle methanolic extract was active as
complementary therapy of malaria (IC50=0,013 mg/grbb).
Keywords: malaria, bangle,
n-hexane, complementary therapy
Penulis: Sugiyanta
Kode Jurnal: jpkesmasdd170067
