Hubungan antara Profilaksis Kotrimoksazol dan Prevalensi Toksoplasmosis pada Pasien HIV Positif di Jember
ABSTRACT: Human
immunodeficiency virus (HIV) is a virus that causes acquired immune deficiency
syndrome (AIDS). HIV is a high mortality disease and the number of patients is
increasing recent days. Based on dr. Soebandi Jember Hospital report in 2015,
there were 1,492 HIV patients and 455 people received antiretroviral (ARV)
therapy. Toxoplasmosis is one of opportunistic infections commonly found in HIV
patients in central nervous system. WHO has issued guidelines for the use of cotrimoxazole
as prophylaxis in HIV positive people. The purpose of this study was to
determine the relationship between cotrimoxazole prophylaxis and the incidence
of toxoplasmosis. This research was a case control study with retrospective
approach and used chi-square analysis. The results showed that most patients
were male (57%), 20-29 years in age (50%), and 41-60 kg in weight (64%). Based
on the CD4 level, most HIV patients were less than 350/mm3 (96%) and total
lymphocite count (TLC) also less than 1,200/mm3 (42%). There were 1 patient
from 76 patients with cotrimoxazole prophylaxis and 7 patients from 52 patient
without cotrimoxazole prophylaxis who developed toxoplasmosis. Based on
chi-square analysis, cotrimoxazole prophylaxis reduce the incidence of toxoplasmosis
in HIV positive (p-value 0,004).
Keywords: HIV/AIDS,
prophilaxis therapy of cotrimoxazole, toxoplasmosis infection
Penulis: Elly Febry Taufany
Kode Jurnal: jpkesmasdd180013
