Indeks massa tubuh, asupan vitamin D, dan serum 25-hydroxyvitamin D pada pasien kanker payudara
Abstract: Breast cancer is the
most common malignancy in women in the world. Vitamin D helps control the
majority of gene expression in female reproductive tissues. Body mass index
(BMI) influences the bioavailability of vitamin D. Diet is one of the main
sources of vitamin D and it is directly converted into 25-hydroxyvitamin D [25
(OH) D] in the liver.
Objective: This study aimed to analyze the relationship between BMI and
vitamin D intake and 25 (OH)D serum in patients with breast cancer.
Method: Analytic observational with cross sectional design was used in
this study. A total of 37 breast cancer patient visited Dr. Moewardi Hospital
in Surakarta was selected as research subjects using a purposive sampling
technique. BMI data was obtained by measuring body weight and height. Vitamin D
intake was determined using 1 x 24-hour food recall and semi-quantitative food
frequency questionnaire. While, 25(OH)D serum was measured using enzyme-linked
immunoabsorbent assay. Data analysis used Spearman correlation test.
Results: The averages of BMI, vitamin D intake and 25(OH)D serum of
breast cancer patients were 21.96±3.63 kg/m², 3.50±3.30 µg/day and 16.01±14.67
ng/mL respectively. Most breast cancer patients had less vitamin D intake and 25(OH)D
serum deficiency. There was a weak relationship between BMI (r=0.188, p=0.266)
and vitamin D (r=0.113, p=0.507) and 25 (OH)D serum in breast cancer patients.
Conclusion: There were no significant correlations between BMI and
vitamin D intake with 25(OH)D serum in breast cancer patients. Further study is
required on the effect of chemotherapy regimens on vitamin D metabolism.
Keywords: BMI; breast cancer;
vitamin D intake; 25(OH)D serum
Penulis: Amilia Yuni Damayanti
Kode Jurnal: jpkesmasdd170484
