Kadar IL-10 Mencit Balb/C Terinfeksi Plasmodium berghei dengan Pemberian Fraksi Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer
ABSTRACT: Malaria is an
infectious disease caused by Plasmodium spp. The cause of mortality in malaria
is the parasite’s resistance to malaria drugs and immune system problem.
Interleukin-10 is an anti-inflammatory cytokine during plasmodium infection.
Bangle is a herbal remedy that contains high amount of curcumin showing
immunostimulant activity. The purpose of this study was to determine the
difference of IL-10 level in Plasmodium berghei-infected Balb/C mice given with
methanolic fraction of bangle (Zingiber cassumunar Roxb.) as a complementary
therapy. This study was a true experimental with posttest control group design
using 25 mice Balb/c which divided into 5 groups (A, B, C, D and E). All groups
except group A were infected with P. berghei. After positively infected, group
B was not treated, C was treated with artemisinin, group D was given with
artemisinin and methanolic fraction bangle 0,017 mg/gBW, group E was treated
with methanolic fraction bangle 0,017 mg/gBW. The result showed that group D
had the highest-level of IL-10 among the treatment groups. The Post Hoc LSD
test showed p value ≥ 0,05. In conclusion, there was no significant difference
of IL-10 serum level in P. berghei-infected Balb/C mice given with methanolic
fraction of bangle (Z. cassumunar Roxb.) as complementary therapy.
Keywords: Interleukin-10,
Plasmodium berghei, Bangle (Zingiber cassumunar Roxb.)
Penulis: Asis Fitriana, Bagus
Hermansyah, Muhammad Afiful Jauhani, Wiwien Sugih Utami
Kode Jurnal: jpkesmasdd180022
