Keseimbangan asam-basa tubuh dan kejadian sindrom metabolik pada remaja obesitas
Abstract: The prevalence of
metabolic syndrome increased in young population, indicated by the rise in
obesity among children and adolescent. The Western dietary pattern was one of
the causes. A Western diet rich in animal protein can produce acid during the
metabolic process and may cause an acid-excess in the body (dietary acid load).
This process was contributed to acid-base balance through the metabolism of
sulfur-containing amino acids (cysteine and methionine) which produce H+ ions
as well as lowering the pH.
Objective: To examine the association between acid-base balance and
components of metabolic syndrome among obese adolescent.
Method: A cross-sectional study was conducted on 40 obese adolescents in
Semarang high school. We measured Potential Renal Acid Load (PRAL) score and pH
urine as an acid-base indicator. MetS are defined ≥ 3 following risk factors:
waist circumference ≥90th percentile, blood pressure ≥90th percentile,
triglycerides ≥110 mg/dl, HDL levels ≤40 mg/dl, and fasting blood glucose
levels ≥110 mg/dl. Normality test used the Shapiro-Wilk test (n <50). The bivariate
analysis used Pearson test, Rank-Spearman test, and Chi-Square test. The
multivariate analysis used Multivariate Linear Regression analysis of Backward.
Results: PRAL score was associated with waist circumference (r=0,347;
p=0,028), sistolic blood pressure (r=0,590; p=<0,001), diastolic blood
pressure (r=0,668; p=<0,001), and triglyceride levels (r=0,362; p=0,022). pH
urin was not associated with any risk factors of MetS.
Conclusion: High dietary acid load may be a risk factor for the
development of MetS.
Keywords: adolescent; blood
pressure; dietary acid load; obesity; PRAL score; trygliceride; waist
circumference
Penulis: Firdananda Fikri
Jauharany
Kode Jurnal: jpkesmasdd170542
