Optimasi Hidroksipropil Metilselulosa dan Mentol pada Sediaan Gel Dispersi Padat Ibuprofen–Polietilenglikol dengan Metode Desain Faktorial
ABSTRACT: Ibuprofen is
included in non-steroidal anti-inflammatory drug (NSAID) which is used for the
treatments of arthritis and inflammation. Ibuprofen gel is an effective
approach evading ibuprofen's side effect in GI tract and first pass effect. The
aims of this study was to determine the effect of HPMC and menthol combination
on viscosity, penetration flux and to obtain the optimum formula.The gel
evaluations were organoleptic testing, pH, viscosity, spreadibility test, assay
of ibuprofen gel, and in vitro penetration rate. In vitro penetration testing
used the paddle type dissolution tester. Furthermore ibuprofen which penetrated
through rat skin were analyzed by UV-Vis spectrophotometer. Ibuprofen gel were
prepared into four formulas based on factorial design and the data were
analyzed using design expert trial 9.0.3. The viscosity testing of F1, Fa, Fb,
and Fab were 183.30 ± 14.433,261.67 ± 16.07, 158.33 ± 7.637, and 310.0 ± 13.23
dPa.s. The in vitro penetration rate of F1, Fa, Fb, and Fab were 0.7225,
0.6716, 1.5587 And 1.0702 µg/cm2.minutes. It can be concluded that Fb has the
optimum formula.
Keyword: optimization, HPMC,
menthol, factorial design
Penulis: Maharani Dwi Pratiwi,
Dwi Nurahmanto, Viddy Agustian Rosyidi
Kode Jurnal: jpkesmasdd170095
