Optimasi Komposisi Polietilen Glikol dan Lesitin sebagai Kombinasi Surfaktan pada Sediaan Nanoemulsi Kafein
ABSTRACT: Caffeine is one of
alkaloids that have the potential to skin cancer treatment. Caffeine is
hydrophilic with log-P value of 0.07 that makes difficult to penetrate to the
stratum corneum. Nanoemulsion is one of system which made to increase drug
penetration. One of the important component in the nanoemulsion is a surfactant
that acts as a unifier between the oil and water phases to form one phase that
isotropic and thermodynamically stable. The presence of lipophilic component in
the surfactant can affect the skin barrier disturb, thus increasing
penetration. The aims of this study was to find the best composition of the
PEG-400 and lecithin as surfactant combination to obtain a nanoemulsion that is
safe, stable, and increasing penetration of caffeine. The experiment was
conducted using a factorial design method which observed responses of flux
value and viscosity deviation. The viscosity deviation and flux were analyzed
using Design Expert 10.0 trial to determine the optimal formula of caffeine
nanoemulsion. The results obtained optimal formula of nanoemulsion that has
composition of PEG-400 as 32% and lecithin as 7% . Prediction of viscosity
deviation and flux value of optimal formula was 0,034 cP and 0.514 µg
cm-2min-1.
Keywords: caffeine,
nanoemulsion, PEG-400, lecithin
Penulis: Dessy Dwi Risky
Ayuningtias
Kode Jurnal: jpkesmasdd170056
