Optimasi Konsentrasi Hidroksipropil Selulosa dan Polivinilpirolidon dalam Sediaan Buccal Film Simvastatin
ABSTRACT: Simvastatin, an
antihyperlipidemia drug belongs to HMG-CoA reductase inhibitor, has extend
first-pass metabolism and low bioavailability (5%) with 95-98% protein bond and
short half-life (2 hours). The problem of low bioavailability can be solved by
buccal delivery systems with producing simvastatin mucoadhesive buccal film.
Concentration of HPC and PVP can affect the value of simvastatin release and
mucoadhesive strength of film. Optimization using factorial design method
determine the optimum concentration of HPC and PVP with highest simvastatin
release and mucoadhesive strength. Solvent casting method used for preparation
of 4 formula according to factorial design. The result was formula A (FA) with
HPC and PVP concentration ratio (50: 10) gave the highest simvastatin release
at 95.41% and the highest mucoadhesive strength at 73.37 grams. FTIR analysis
results of FA indicated that there were no change in the functional groups on
simvastatin as an active ingredient, and the mucoadhesive residence time showed
that FA buccal films can be attached to the goat buccal tissues for 186
minutes.
Keywords: Buccal film,
mucoadhesive, simvastatin, HPC, PVP, factorial design
Penulis: Nurul Qomariyah, Lidya
Ameliana
Kode Jurnal: jpkesmasdd170040
