Optimasi Propilen Glikol dan Etanol sebagai Peningkat Penetrasi Ibuprofen dalam Sediaan Gel dengan Metode Simplex Lattice Design
ABSTRACT: Ibuprofen is a
non-steroid anti inflammatory drug (NSAID) used for rheumatoid arthritis
treatment. In this study, formulation, evaluation, and optimization of
ibuprofen gel formula were conducted in order to determine the best ibuprofen
penetration rate through the rats skin using propylene glycol and ethanol as
penetration enhancers and to find out the optimum formula to get the best
penetration rate with simplex lattice design method. Evaluations included
organoleptic, pH, viscosity, gel dispersive, assay of gel formulations, and
ibuprofen penetration rate assay. Penetration rate was determined by paddle
type dissolution and the samples were analyzed by spectrophotometry UV-Vis. The
results of ibuprofen penetration rate assay were analyzed and optimized using
design expert trial version 10. The results of ibuprofen penetration rate were
F1 1.524 ± 0.121 µg/cm2.minute; F2 1.945 ± 0.0104 µg/cm2.minute; and F3 1.173 ±
0.216 µg/cm2.minute. Penetration rate optimization resulted in one optimum
solution formula which was 18.000% propylene glycol and 12.000% ethanol with a
maximum flux of 1.957 ug/cm2.minute and desirability 1. It can be concluded
that the best ibuprofen penetration rate was F2 with flux 1.945 ± 0.0104
µg/cm2.minute with 15% propylene glycol and 15% ethanol.
Keywords: gel, ibuprofen,
propylene glycol, ethanol, simplex lattice design
Penulis: Baiq Wahyudyati
Karnia Qisti
Kode Jurnal: jpkesmasdd180011
