Optimasi Sintesis Asam 3-benzamido-4-metil benzoat (Optimization Synthesis 3-benzamido-4-Methyl Benzoic Acid)
ABSTRACT: Benzoic acid
derivative has been developed as new drugs that have antioxidant, antifungal,
analgesic, anti-cancer, anti-inflammatory, and anti-herpes simplex virus
activity. In this study, a new compound of benzoic acid derivative,
3-benzamido-4-methyl benzoic acid (3-BM) was synthesized by reacting
3-amino-4-methyl benzoic acid with benzoyl chloride. This study used
benzoylation reaction with Schotten-Baumann method. Temperature, time, and TLC
mobile phase were needed to be optimized to make optimum condition, so the
synthetis reaction can be done. The reaction time was 24 hours, the samples
were taken at 1,2,3,4,5,6,12,24 hours then spotted on TLC plates and eluated
with optimum eluent chloroform: ethyl acetate: acetic acid (100:5:1). 3-BM
compound can be synthesized by benzoylation reaction with optimum synthesis
condition at room temperature 25-27 °C and 2 hours reaction time.
Keywords: synthesis, benzoic
acid derivative, 3-benzamido-4-methyl benzoic acid, benzoyl chloride
Penulis: Muh Agus Mauluddin, Dian
Agung Pangaribowo, Indah Purnama Sa
Kode Jurnal: jpkesmasdd170132
