Optimasi Sodium Starch Glycolate dan Crospovidone sebagai Superdisintegran dalam Sediaan Orally Disintegrating Tablet Meloksikam
ABSTRACT: Meloxicam is the
second class of biopharmaceutical classification system that its solubility
needs to be improved. Therefore, in this study solid dispersion of meloxicam
were prepared using PEG 6000. Meloxicam is used to treat osteoarthritis that
particularly experienced by geriatric patients. Geriatric patients have a
difficulty to swallow conventional capsule or tablet, but orally disintegrating
tablet (ODT) overcome this difficulty. The basic of ODT formulation is the use
of superdisintegrant, like sodium starch glycolate (SSG) and crospovidone. The
aim of this study was to find out the combination of superdisintegrant that
shows optimum fomulation. The effect of superdisintegrant and their combination
on hardness, friability, disintegration time and percentage of drugs released
in 30 minutes (T30) also investigated. The design of formula used the simplex
latice design with two component mixture: SSG and crospovidone. Results showed
that the combination affected not significantly on disintegration time and
friability of ODT, but they could improve hardness and T30. The optimum formula
found at combination of 0 mg SSG and 8 mg crospovidone in 200 mg tablet.
Keywords: meloxicam, sodium
starch glycolate, crospovidone, ODT, simplex lattice design
Penulis: Eunike Aprilianio, Lusia
Oktora Ruma Kumala Sari, Eka Deddy Irawan
Kode Jurnal: jpkesmasdd170091
