Pemberian minyak ikan lele (Clarias gariepinus) terhadap bobot badan dan perubahan histopatologi hati, ginjal, dan otak tikus galur Sprague dawley yang diberi pakan hiperkolesterolemia
Abstract: The objective of
this study was to analyze changes in body weight and cell morphology in liver,
kidney and brain tissue of Sprague dawley rats administered hypercholesterolemia diets for four weeks.
Four diet treatments were applied in this study: control, catfish oil, catfish
oil with the addition of omega 3 and catfish oil with the addition of omega 3
and vitamin E. Four weeks after the intervention, the rats were sacrificed and
the internal organs (liver, brain, and kidney) were taken for histological preparations
by hematoxylin-eosin (HE) and immunohistochemistry test. The study showed that
the catfish oil intervention tend to reduced weight gain of rats fed
hypercholesterolemia diets. More lipid accumulation in liver of the control
group was found than the intervention groups. However, there was no difference
in the histopathology of the kidney and brain tissues between the control group
and intervention groups. It is concluded that catfish oil study provides a
positive effect in rat liver tissue, but no difference exists between the brain
and kidney tissue. There is no defect found at hippocampus of rats by formed of
amyloid plague.
Keywords: brain; catfish oil;
histopathology; kidney; liver
Penulis: Hardi Firmansyah,
Katrin Roosita, Clara Meliyanti Kusharto, Ekowati Handharyani
Kode Jurnal: jpkesmasdd170521
