Pemberian tempe menurunkan kadar malondialdehyde (MDA) dan meningkatkan aktivitas enzim superoxide dismutase (SOD) pada tikus dengan aktivitas fisik tinggi
Abstract: The aim of this
research was to analyze the influence of tempe giving to the oxidative stress
in rats with high physical activities. This research was true experimental
post-test only with control group design on 35 rats. The rats were given high
physical activities and tempe treatments for 30 days. Those rats were divided
into 5 group, which were: control 1 without giving tempe and supplement,
control 2 with the giving of the commercial supplement, treatment 1 with giving
0.75 g tempe/200 g of body weight/day, treatment 2 with giving 1.5 g tempe/200
g of body weight/day and treatment 3 with giving 3 g tempe/200 g of body
weight/day. At the end of this research, it was done the examination of the
plasma MDA level by using TBARS method and activities of SOD enzyme using
spectrofometry. The statistical analysis used One-way ANOVA Tests and Post Hoc LSD.
The result showed that the tempe giving at various doses was significantly
influenced to the reduction of MDA level (p<0.05) and also significantly
influenced to the increasing activities of SOD enzyme (p<0.05). The giving
of 3 g tempe was the most effective dose to the reduction of MDA level and the
increasing activities of SOD enzyme. The conclusion was tempe could decrease
the MDA level and increase the activities of SOD enzyme significantly in
oxidative stress rats with high physical activities.
Keywords: antioxidant; high
activities; MDA; oxidative stress; SOD; tempe
Penulis: Iriyanti Harun,
Hardhono Susanto, Ali Rosidi
Kode Jurnal: jpkesmasdd170485
