Pengaruh Besar Ukuran Partikel Terhadap Sifat – Sifat Tablet Metronidazol
Abstrak: The influence of
particle size toward the characteristics of Metronidazole tablets has been
studied. Metronidazole that is used for first formua is not crushed, for the
second formula is used Metronidazole powder cruhed for 30 minutes, and for the
third formula is used Metronidazole powder that is crushed for 3 hours. The
crushing process of the powder is done by using Ball mill. The result is
analysed by SEM, DTA, FT IR, and particle distribution. DTA data (mettler
Toledo) shows the changing of thermodynamic characteristics that occurs when
the sample is given heat energy in form of melting shown by endoterm. From the
three formula are made Metronidazole tablets by using wet granulation. The
formulations of Metronidazole use mucilago gelatin as a binder, lactose as
excipients, amylum as desintegrant and aerosil as a lubricant. Tablet
evaluation involves the same size, same weight, the strength determining of
level and dissolution. Dissolution test is done by using basket method and the
level determined by the method of UV Spectrophotometer at the maximum absorption wavelength of 276.5
nm in HCl 0,1 N. The result of the assay formula 1 is 82,6248%, the formula 2
is 87.3086% and the formula 3 is 95.7037%. Result of dissolution measurement at
60 minutes showed that the average dissolution is 47.902%, 68,584% and 69.320%.
The dissolution profile test uses HCl 0,1 N. The analysis of dissolution
profile is done by the equality orde 0, orde 1, Higuchi and Korsmeyer peppas.
Dissolution profile of Metronidazole tablets approach to Korsmeyer peppas.
Kata Kunci: metronidazole,
particle size, tablet
Penulis: Maria Dona Octavia,
Auzal Halim, Rika Indriyani
Kode Jurnal: jpfarmasidd120273
