Pengaruh Faktor Klinik dan Pengobatan terhadap Keberhasilan Terapi Tuberkulosis pada Pasien HIV–TB di Jember
ABSTRACT: Human
imunodeficiency virus (HIV) is an infectious diseases that become an
international problem. Since 1980s, there was an increase in morbidity and
mortality due to tuberculosis (TB) infection in high HIV prevalence areas. The
success of therapy is very important in the treatment of HIV-TB patients. The
purpose of this study was to determine the factors that influence the success
therapy in HIV-TB patients. This research was a cross sectional study with
retrospective approach and used chi square analysis. The result showed that
most patients were male (62.1%) and most were 25-34 years in age (42.3%). Most
HIV-TB patients were 41-50 kg in weight (56.9%). They had CD4 level range of
50-199/mm3 and total lymphocyte count (TLC) less than 1,200/mm3 (58.6%). Most
HIV-TB received therapy TB category 1 that was 55.2%, and antiretroviral (ARV)
combination of TDF+3TC+EFV (91.8%). Based on chi square analysis, body weight,
CD4 level, and TLC affected the success therapy (P value 0.022, 0.003, 0.028),
whereas age and gender didn't (P value 0.222, 0.905). On the other hand, the variation therapy of TB and HIV didn't affect
the success therapy either (P value 0.943, 0.718).
Keywords: HIV-TB,
antiretroviral, tuberculosis therapy
Penulis: Nuraini Agustin, Afifah
Machlaurin, Prihwanto Budi Subagio, RSD dr. Soebandi Jember
Kode Jurnal: jpkesmasdd170086
