Pengaruh Minyak Ikan Lemuru (Sardinella longiceps) terhadap Ekspresi Tumor Necrosis Factor (TNF-α) Kartilago yang Diinduksi Complete Freund's Adjuvant
ABSTRACT: Osteoarthritis is a
chronic joint disorder with weakening and disintegration of the joint cartilage
followed by the growth of new bone and cartilage. TNF-α is one of the
inflammatory mediator that plays an important role in the progression of
osteoarthritis. In the others hands, lemuru (Sardinella longiceps) fish oils
that contain EPA and DHA has an anti-inflammatory effect. The purpose of this
study was to investigate the effect of lemuru fish oil on decreasing the
expression of TNF-α in cartilage that induced by Complete Freunds Adjuvant.
This was a experimental design study with randomized post test only control
group design. The sample was divided into 2 groups: the negative control group
(K-) and the treatment group (P), each group was divided into three subgroups
based on duration of lemuru fish oils treatment, 7th, 14th and 21st days. TNF-α
expression data was obtained from immunohistochemical observations on
tibiofemoral articular cartilage. The result showed that the expression of
TNF-α in the treatment group is lower than the negative control group and One
Way Anova test showed that there is significant difference between groups (p =
0.000). We can conclude that lemuru (Sardinella longiceps) fish oil decreased
the expression of TNF-α.
Keywords: Osteoarthritis,
TNF-α, lemuru (Sardinella longiceps) fish oil, cartilage
Penulis: Kiki Andari, Rena
Normasari, Muhammad Hasan
Kode Jurnal: jpkesmasdd170033
