Pengaruh Pemberian Niasin dan Kafein dalam Model Minuman Berenergi terhadap Fisiologi Hati Tikus Wistar Jantan
ABSTRACT: Recently,there are
many hepatotoxicity case reports induced by energy drinks and its niacin
content is assumed to be the cause of liver injury. Caffeine in energy drinks
actually has a hepatoprotective effect. However, this hepatoprotective effect
of caffeine is less potent in counteracting the hepatotoxic effect of niacin.
This study aimed at determining niacin and caffeine influences in inducing the
disruption of liver physiology and the dose of niacin and caffeine in energy
drink model which can induce the disruption of liver physiology by measuring
AST, ALT, and GGT. As many as 28 male albino wistar rats were divided into
seven groups;1 control group and 6 experimental groups, for 49 days. At day
50th, the rats were terminated to measure the AST, ALT, and GGT. The AST and
ALT enzyme levels were not significantly correlated (p> 0,05). Otherwise,
the GGT enzyme level was significantly correlated (p<0,05). It was showed
that niacin and caffeine elevate GGT enzyme at doses 0,491 mg/ 200gr body
weight/ day niacin and 1,2275 mg/ 200gr body weight/ day caffeine. These doses
are equal to the consumption of three packs of energy drinks per day in human.
Keywords: niacin, caffeine,
energy drinks, AST, ALT, GGT
Penulis: Ngurah Agung Reza
Satria Nugraha Putra, Erma Sulistyaningsih, Jauhar Firdaus
Kode Jurnal: jpkesmasdd170104
