PENGARUH TERAPI TAMBAHAN ASAM FOLAT DAN KOBALAMIN TERHADAP GEJALA SKIZOFRENIA KRONIK
Abstract: Folic Acid,
Cobalamin, Symptoms, Schizophrenia. Schizophrenic patients have low levels of
folic acid and cobalamin. Deficiency of folic acid and cobalamin can cause
neurological and psychiatric disorders. Supplementation of folic acid and
cobalamin may provide therapeutic benefits through different mechanisms of
current treatment regimens. To assess the effectiveness of additional therapies
of folic acid and cobalamin in improving the negative symptoms and length of
stay of chronic schizophrenic patients. This study was an experimental study
with randomized controlled trial group, pre-post test design. The intervention
group had significant PANSS score improvementin positive symptoms (p = 0,01),
negative symptoms (p = 0,004), general psychopathologies (p = 0,01) and PANSS
total score (p = 0,014) subscales. ONE-WAY ANAVA statistic analysis result
shows significant reduction in all four subscales (p = 0,000). Adding folic
acid and vitamin B12 as adjuvant therapy with standard antipsychotic medication
effective in reducing chronic schizophrenia symptoms.
Keywords: Folic Acid,
Cobalamin, Symptoms, Schizophrenia
Penulis: Betty Hidayati, Aris
Sudiyanto, Moh Fanani
Kode Jurnal: jpkesmasdd170227
