Penggunaan Biopolimer Polikaprolakton Sebagai Matrik Herbisida Lepas Lambat Asam 2,4-Diklorofenoksi Asetat
Abstrak: The formulation of
microcapsule of 2,4-dichlorophenoxy acetate acid using biopolymer
polycaprolactone as a matrix using solvent evaporation method has been carried
out. The microcapsule formula was used three types with the ratio 2:1, 1:1, 1:2
between 2,4-dichlorophenoxy acetate acid and polycaprolactone. Distribution
particle test was used calibrated microscope. Active substance release test was
detected by UV-Vis spectrophotometer. Polycaprolactone can be used as the
matrix polymer for slow release preparations and influence to the release of
active substance 2,4-dichlorophenoxyacetate acid. Result showed that recovery
test of the formula-2 containing 86.5 % higher than formula-1, 84.5% and
formula-3 78.2%. Model of the kinetics of the release active substance from
microcapsule which correlation coefficient close to one is formula-1 which
follow zero order kinetics.
Kata Kunci: polikaporolakton,
2,4-D, herbisida
Penulis: Akmal Djamaan, Maria
Ulfa, Netty Suharti
Kode Jurnal: jpfarmasidd120278
