Potential of okra (Abelmoschus esculentus L.) extract to reduce blood glucose and malondialdehyde (MDA) liver in streptozotocin-induced diabetic rats
Abstract: The study aimed to analyze
the potential of okra to reduction blood glucose and MDA liver in
streptozotocin (STZ)-induced diabetic rats. Design experiment used in this
study was pre and post test controlled group design. The first step of this
study was analyzed bioactive compound of okra extract. The next step was
administired orally of okra extract to control and diabetic rats induced by
streptozotocin 50 mg/kgBW for 14 days. Sprague dawley rats were divided into
six groups: normal control (N), diabetic control (DM), diabetic treated with
green okra extract (GOE) with the dosage of 5 mg/kgBW quercetin and 10 mg/kgBW
quercetin, diabetes treated with purple okra extract (POE) with the dosage of 5
mg/kgBW quercetin and 10 mg/kgBW quercetin. Blood glucose were measured each five
days and malondialdehyde (MDA) liver in rats were measured in the end of
intervention. The following results show that phenolic and quercetin of purple
okra extract were higher (3.60%; 0.45 mg/g) than green okra extract (3.58%;
0.27 mg/g). Administration of GOE I, GOE II, POE I and POE II in diabetic rats
showed significant (P<0.05) reduction in blood glucose level (115.25 mg/dl;
86 mg/dl; 180.75 mg/dl; 91 mg/dl) and improve level of MDA. These results
suggest that intervention of okra extract based on quercetin compound show an
antihyperglicemic potential and improve MDA level.
Keywords: blood glucose;
diabetic rats; malondialdehyde; okra extract; streptozotocin
Author: Putri Puncak Anjani,
Evy Damayanthi, Rimbawan, Ekowati Handharyani
Journal Code: jpkesmasgg180024
