Sintesis dan Uji Aktivitas Antibakteri Senyawa N-Fenil-3,4-Diklorobenzamida
ABSTRACT: In this research,
the synthesis of N-phenyl-3,4-diklorobenzamida was carried out by reacting
1,3-diphenylthiourea and 3,4-dichlorobenzoil chloride via bimolecular
nucleophilic substitution reaction (SN2). The assays for the obtained compound
product were purity test (tested by TLC and melting point tester), chemical and
physical characterization (shape, color, and solubility), confirmation of the
compound and structure (performed by UV-Vis spectrophotometer, FTIR
spectrometer, 1H-NMR and 13C-NMR). The result showed that the compound was
synthesized successfully with a yield of 42%, then the in vitro test of
antibacterial activity against Staphylococcus aureus ATCC 6538 and Pseudomonas
aeruginosa ATCC 27853 was conducted by well diffusion method. The compound
N-phenyl-3,4-dichlorobenzamida did not have antibacterial activity which showed
by the absence of inhibition diameter.
Keywords:
1,3-diphenylthiourea, N-phenyl-3,4-dichlorobenzamide, nucleophilic
substitution, antibacterial
Penulis: Vinastika Gita
Yualanda
Kode Jurnal: jpkesmasdd180010
