Studi Sistem Dispersi Padat Meloksikam Menggunakan Hiroksipropil Metilselulosa (HPMC) 6 Centipoise (CPS)
Abstrak: The solid dispersion
system of meloxicam-hydroxypropyl methylcelluloce (HPMC) 6 centipoise (cps) had
been studied. The solid dispersion system was prepared by solvation method with
several combination of meloxicam and HPMC were 1:1, 1:3 and 1:5. The physical
mixture of meloxicam and HPMC with similar composition were used as standard.
The powder of solid dispersion system and physical mixture were evaluated by
X-ray powder diffraction, thermal (DTA), SEM and FT-IR spectroscopy analysis.
The dissolution studies were carried out in USP type II apparatus. The result
of X-ray powder diffraction analysis showed that the solid dispersion of meloxicam with HPMC decreased the drug
crystallinity. The endothermic peak of meloxicam from solid dispersion products
shifted to lower temperature and peak intensity decreased significantly. X-ray
powder diffraction and DTA indicated transformation of crystalline state of
meloxicam to amorphous one by solid dispersion with HPMC. SEM results showed
the solid dispersion of meloxicam and HPMC has agglomerates form. FT-IR spectra
indicated no chemical interaction between meloxicam and HPMC in the solid
dispersion. The highest in dissolution rate was observed with solid dispersion
products of meloxicam and HPMC with ratio 1:5 (94,083 %) compared to pure
meloxicam and its physical mixture.
Kata Kunci: eloxicam, solid
dispersion system, HPMC 6cps
Penulis: Erizal Zaini, Maria
Dona Octavia, Kiki Rizky Wirza
Kode Jurnal: jpfarmasidd120272
