The safety evaluation of ethanol extract of torbangun leaves (Coleus amboinicus Lour.) on mouse fetal development
Abstract: The purpose of this
study was to evaluate the safety of ethanol extract from torbangun leaves on
mouse fetal development. This research used 24 female pregnant mouse. The
leaves extract was administered orally at dose level of 0; 0.56; 1.68 and 3.36
g/kg body weight. The extract was given from the first day until the eighteenth
day of pregnancy period. The ethanol extract of Torbangun leaves contains
flavonoids, saponins, tannins, and steroids. The result showed that consumption
of 3.36 g/kg torbangun leaves extract had led to significant differences in the
decrease of maternal weight change, number of live fetuses, fetal weight, and
fetal length. Consumption of Torbangun leaves extract during pregnancy should
be avoided due to its potency to interfere the fetal development.
Keywords: ethanol extract;
pregnancy; teratogenicity; Torbangun
Author: Elma Alfiah, Muhammad
Rizal Martua Damanik, Katrin Roosita, Mokhamad Fahrudin
Journal Code: jpkesmasgg180021
Artikel Terkait :
Jp Kesmas gg 2018
- The application of probability method to estimate micronutrient deficiencies prevalence of Indonesian adults
- Nutritional status of exclusive compared to non exclusive breastfeeding mother
- Potential of okra (Abelmoschus esculentus L.) extract to reduce blood glucose and malondialdehyde (MDA) liver in streptozotocin-induced diabetic rats
- Application of alternate healthy eating index to assess diet quality in male workers
- Hydration status and liver function of young men before and after Ramadan fasting
- Effectiveness Leadership and Optimalization of Local Potential in Nutrition Status Improvement Effort
- Efficacy of Propolis Supplementation to Accelerate Healing Process and Body Weight Recovery of Pulmonary Tuberculosis Patients
- Relationship between Oral Hygiene and Dietary Behaviour and Dental Caries Status in Primary School Children
- Usage of Fruit-Infused Water for Prevention of Dehydration Due to Endurance Exercise
- IMPROVING ELDERLY’S QUALITY OF LIFE THROUGH FAMILY ROLE
- The Potency of Polygamy Behavior in Aedes aegypti Mosquitoes by Venereal Transmission Dengue Virus
- Effect of Climatic Factors and Habitat Characteristics on Anopheles Larval Density
- Effectiveness of Smartphone Application “Nutriatlet” in Increasing Energy Intake of Martial Arts Athletes
- ACTORS CONTRIBUTING IN THE DECLINE OF MATERNAL MORTALITY AND LABOR SERVICES PROBLEMS
- Benefit of Childbirth Care Counseling for Mood of Postpartum Period
- Effects of Areca Catechu L. Seed Extract on Mortality Anopheles Vagus Larvae
- Effectiveness of Virgin Coconut Oil and Virgin Olive Oil on Perineal Laceration
- The Combination of Probiotic and Calcium Carbonate Decrease Monocyte Count of End-Stage Renal Disease Patient
- Development Model of Household Contacts as a Peer Support to Decrease the Prevalence of Pulmonary Tuberculosis
- Midwife’s Knowledge and Attitude in Kangaroo Mother Care To Premature Neonatal in the Public Health Centre in Batang
- Family Structure and Early Marriage on Women in Indramayu Regency
- Soil Transmitted Helminths Infection in Elementary School Students in Highland and Lowland Areas of Gianyar Regency
- The Description of Larva Free Index as COMBI (Communication for Behavioral Impact) Dengue Hemorrhagic Fever Prevention Indicator
- The Impact of Environmental Changes Caused by Earthquake Toward Emotional Problems of Preschool Children