Uji Toksisitas Subkronik Jamu Asam Urat pada Hati Mencit Galur Balb-C
ABSTRACT: Jamu asam urat is
one of the most-consumed herbal medicine product to threat gout arthritis. This
study aimed to determine of jamu asam urat effect for long-term consumption on
mice's liver. Mice were divided into 4 groups of 10 each group. A control group
was administered with aquadest and 3 treatment groups were administered with
jamu sample per oral in dose of 1,800 (D1); 3,600 (D2); and 7,200 mg/kg BW (D3)
in 28 days. The examination included GPT and GOT serum level measurement and
liver histopathology. The result showed that GPT serum level was 34.33 ± 2.48
U/L (D1), 41.20 ± 1.94 U/L (D2), and 46.32 ± 2.84 U/L (D3), while GOT serum was
44.60 ± 2.94 U/L (D1), 55.53 ± 3.22 U/L (D2), and 63.31 ± 2.63 U/L (D3),
respectively. Parenchymatous degeneration and necrosis in liver were found in histopathology
examination. Increase of GPT, GOT level, and parenchymatous degeneration liver
changes at D1 and D2 counted as mild degeneration, meanwhile necrosis change at
D3 counted as moderate degeneration but it did'nt greatly affect liver
function. Thus jamu asam urat is still save to be consumed.
Keywords: subchronic toxicity,
jamu asam urat, GPT, GOT, liver histopathology
Penulis: M Nuril Huda, Diana
Holidah, Fifteen Aprila Fajrin
Kode Jurnal: jpkesmasdd170041
