A Study on Clinical Assessment of Antibiotic Used in Chronic Kidney Disease Patients
Abstract: A 6-week
longitudinal prospective study was conducted to assess the effectiveness and
the safety antibiotic used in chronic kidney disease (CKD) patients in internal
medicine ward. We comparedwhite blood count and glomerular fi ltration rate
before and after antibiotic used. The CKD patientswho admitted in the internal
medicine ward and age ≥18 years old were included this study. Patientswith
incomplete laboratory data and renal replacement therapy were excluded in this
study. The 25patients who enrolled in this study were recruited. The majority
gender of CKD was male (64%), the mean of age was 61.52±14.17 years old with
length of stay (LOS) was 6.92±4.05 days. The highest number of patients was in
CKD stage 3 (n=10, 40%) and was followed by CKD stage 2 (n=6, 24%).Most of them
were diagnosed community acquired pneumonia. Tablet azithromycin (n=16, 64%)
then Cefotaxime intra venous injection (IV) (n= 6, 24%), and Ceftazidime IV
(n=5, 20%), Cloxacillin IV (n=4, 16%) were the most antibiotics prescribed.
Generally patients had been prescribed appropriate dose of antibiotic and 88%
of them showed improved white blood count. In contrast, the glomerular fi
ltration rate of 44% CKD patients was getting worse. In conclusion, this study
clearly indicate the CKD patients require close monitoring to maintenance of
renal function even the antibiotic had been prescribed appropriately.
Keywords: chronic kidney
disease, antibiotic, clinical assessment
Penulis: MITA RESTINIA, HENNY LUCIDA, WASIF GILLANI S
Kode Jurnal: jpfarmasidd170208
