Activity of Fennel Fruit Extract (Foeniculum Vulgare Mill.) on Uterine of Immature Wistar Female Rat
Abstract: Fennel fruit
(Foeniculum vulgare Mill.) is one of traditional plant medicine known having eff
ects as anti-infl ammatory, analgesic and antioxidant. It also has been reputed
to increase milksecretion, promote menstruation, facilitate birth, alleviates
the symptoms of the male climacteric andincrease libido. Fennel fruit contains
mainly with essential oils, such as anethole. It also contains lignin and fl
avonoids that are predicted having an estrogen-like eff ect or as
phytoestrogen. Phytoestrogen is weak agonists for estrogen and can elicit
statistic signifi cantly increases in uterine wet weight, at defi nite dose, in
the uterothrophic bioassay. It is known that estrogen has eff ect on woman’s
sexualorgan, such as proliferation of uterine, mammary and ovary. The aim of
this research was to investigate the estrogenic eff ect of fennel fruit’s
ethanolic extract in immature, 19 days old, Wistar female rats. These models
represent the climacteric/menopause phase, where estrogen level is very low
becausein this age, estrogen not yet produced by ovary. The testing animals
were divided into fi ve groups, namely normal group, estradiol control group
and three level doses of fennel extract (30 mg/200 g BW;60 mg/200 g BW and 120
mg/200 g BW). The result indicated that start on 60 mg/200 g BW, fennel extract
signifi cantly (α=0.05) increased wet weight of uterine. Fennel extract also
lengthen the uterineand increased proliferation of uterine, such as uterine
diameters, endometrium diameters and uterine thickness on dose 60mg/200gBW and
120mg/200gBW. Analysis of vaginal smear showed vaginal lubrication eff ect,
surprisingly start on 60mg/200BW could induce estrous cycle.
Keywords: Fennel fruit,
phytoestrogen, immature rat, Foeniculum vulgare Mill
Penulis: KURNIA AGUSTINI, DWI
RIANI WULANDARI, LESTARI RAHAYU
Kode Jurnal: jpfarmasidd170205
