AKTIVITAS PENGHAMBATAN EKSTRAK ETANOL DAUN CASSIA SPECTABILIS TERHADAP PERTUMBUHAN PLASMODIUM FALCIPARUM DAN PLASMODIUM BERGHEI
ABSTRACT: Antimalarial
screening against nine species of the genus Cassia showed that the methanol
extract of leaves Cassia spectabilis have the highest activity. Since it will
be used as a traditional medicine, hence it is needed further studies of
antimalarial activity of these plants by choosing a safer solvent, namely
ethanol. Objective: In vitro anti-malarial activity against Plasmodium
falciparum was conducted using the method of Trager and Jensen. Methods: The
serial solution tested were: 100, 10, 1,
0.1 and 0.01 µg/ mL, while the in vivo test was performed based on
Peter’s test (The days suppressive test) that using P. berghei (strain ANKA)
infected mice. Results: The results showed that ethanolic extract of C.
spectabilis leaves has inhibitory activity against P. falciparum with IC50
value of 12.52 µg/ mL and against P. berghei with ED50 value of 131.5 mg/kg
body weight. Conclusions: A further study to see the potential of ethanol
extract from C. Spectabilis leaves as anti-malaria is warranted.
KEYWORDS: C. spectabilis,
Antimalarial, P. falciparum, P. berghei
Penulis: Wiwied Ekasari,
Nindya Tresiana, Suciati Iryani, Tutik Sri Wahyuni, Heny Arwaty
Kode Jurnal: jpfarmasidd160728
