Ameliorative effects of vitamins C and E on tenofovir/nevirapine-induced hepatorenal oxidative stress in albino rats
Abstract: Oxidative stress has
been implicated in xenobiotic-induced hepatorenal toxicity. This research was
designed to investigate the effects of vitamins C and E on the baseline and
tenofovir/nevirapine-induced liver and kidney levels of superoxide dismutase
(SOD), glutathione (GSH), catalase (CAT) and malondialdehyde (MDA) in male
albino rats. Materials and Methods: Forty five male albino rats were used for
this study. The rats were divided into groups A – I of 5 rats each. Group A (placebo control) and group B
(solvent control) were orally treated with water and arachis oil
respectively. Groups C – F were orally
treated with vitamins C, E, vitamins C and E, and tenofovir/nevirapine
respectively. Groups G– I were pretreated with vitamins C, E and vitamins C and
E prior to treatment with tenofovir/nevirapine respectively. Rats were
sacrificed after treatment for 30 days; liver and kidneys were collected and
evaluated for the above parameters. Results: Significant (p<0.05) increases
in the baseline levels of liver and kidney SOD, GSH, and CAT with decreases in
MDA levels were obtained in vitamins C and E treated rats when compared to
control. On the contrary, treatment with tenofovir/nevirapine significantly
(p<0.05) decreased liver and kidney SOD, GSH, and CAT levels with increases
in MDA levels when compared to control. However, all tenofovir/nevirapine
-induced alterations were abrogated in rats pretreated vitamins C and E.
Abrogation was most pronounced in rats pretreated with combined doses of
vitamins C and E. Conclusion: Observations in the present study could be
attributed to the inhibitory effects of vitamins C and E on the oxidative
activity of tenofovir/nevirapine in the liver and kidney of treated rats.
Keywords: tenofovir;
nevirapine; liver; kidney; oxidative stress; antioxidants; rats
Author: Elias Adikwu, Williams
Apiakise
Journal Code: jpfarmasigg160041
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