ANALISIS EFEKTIVITAS BIAYA PENGOBATAN KOMBINASI CANDESARTAN-AMLODIPIN DIBANDINGKAN DENGAN KOMBINASI CANDESARTAN-DILTIAZEM PADA PASIEN HIPERTENSI RAWAT JALAN
Abstract: Hypertension
medication is taken for a long period and thus requires considerable costs. As
antihypertensives vary in efficacy, research is needed to assess the cost
effectiveness of medication, particularly between candesartan-amlodipine and
candesartan-diltiazem combinations on hypertensive outpatients. This study
applied a prospective cohort design with outcome observations for three months
at a private hospital in Yogyakarta. The outcome used to gauge the cost
effectiveness of medication was the achievement of the targeted blood pressure
reduction after treatment. The cost effectiveness analysis was conducted
through payer’s perspective, namely that of the social security agency (BPJS),
with direct medical cost as the cost component measured. Cost effectiveness was
analyzed using an average cost effectiveness ratio (ACER), calculated according
to the ratio of cost to the outcome percentage of the blood pressure reduction
target attainment, and an incremental cost effectiveness ratio (ICER) based on
the ratio between differences in cost and outcome in both medication groups.
The research subjects consisted of 33 patients, 24 of whom underwent medication
with candesartan-amlodipine combination and 9 with candesartan-diltiazem. As
many as 81.82% were female and 72.73% were within the age range of 51-70, while
their most frequent complication was diabetes mellitus (48.48%). Results
revealed the effectiveness of candesartan-amlodipine medication to be 58.33%
with an ACER value of IDR 6,617, whereas that of candesartan-diltiazem was
22.22% with an ACER of IDR 29,733. The ICER value was IDR -7607, indicating
that candesartan-amlodipine was categorically more cost-effective than
candesartan-diltiazem.
Keywords: Cost effectiveness
analysis; hypertension; candesartan-amlodipine; candesartan-diltiazem
Penulis: Faridah Baroroh,
Andriana Sari
Kode Jurnal: jpfarmasidd170477
