ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF AVOCADO SEED (Persea americana Mill.)
Abstract: The purpose of this
research is to evaluate the anti-inflammatory and analgesic activities of
infusion and methanolic extract from avocado seeds. The anti-inflammatory
activity was determined using carrageenan-induced paw edema in mice. The
analgesic activity was assessed using acetic acid stimuli to induce peripheral
pain in mice. Results of this research showed that both all level doses of
infusion and methanolic extract of avocado seeds have a significant reduction
on the mice paw edema. All level doses of methanolic extract of avocado seeds
have a significant reduction on the number of abdominal writhes induced by
acetic acid, but only the lowest dose of infusion showed a significant
reduction. Our findings suggest that avocado seeds contains potential
anti-inflammatory and analgesic compounds which support its traditional use.
Further phytochemical studies are required to determine the active compounds
are actually responsible for such properties.
Keywords: anti-inflammatory;
analgesic; infusion; methanolic extract; avocado seeds
Penulis: Caecilia Desi
Kristanti, Fransisca Puspa Jelita Simanjuntak, Ni Kadek Pramita Anggara Dewi,
Skolastika Venita Tianri, Phebe Hendra
Kode Jurnal: jpfarmasidd170460
