APHRODISIAC ACTIVITY OF ETHANOL EXTRACT OF Cratoxylum sumatranum (JACK) BLUME STEMS ON ISOLATED RAT CORPUS CAVERNOSUM
Abstract: Cratoxylum
sumatranum (Jack) Blume of the Hypericaceae family is known as “Bentaleng” by
Dayak Benuaq. In ethnobotany, Cratoxylum sumatranum stems (CSS) is used as
energy drink or aphrodisiac, but its effect has not been scientifically proven.
Research objective to study the aphrodisiac activity of CSS extract by
screening the aphrodisiac activity in vitro. Method: CSS was collected from
Kutai Kertanegara Regency, East Kalimantan Province. Extraction was by
maceration with ethanol solvent for three days. Re-maceration was done twice.
In vitro screening of aphrodisiac activity used isolated rat corpus cavernosum.
The organ was placed into a 10 mL chamber containing Krebs-Henselheit solution
at pH 7.4, 37°C and aerated with carbogen gas. After acclimation, a contraction
test was performed with phenylephrine solution and after reaching the peak of
contraction at plateau the Control (solvent extract) or CSS ethanol extract was
administerd at cumulatively increased concentration. Vasodilation activity was
known if the contraction response was decreased after the extract’s
administration and expressed in percent contraction with negative value.
Results: CSS ethanol extract induce vasodilatory response on rat Corpus
cavernosum blood vessels. Vasodilation activity is increasing with increasing
concentration of extract given compared to Control. Conclusion the aphrodisiac
activity of CSS ethanol extracts is directly through the vasodilation action
mechanism on blood vessels in the rat corpus cavernosum.
Keywords: Cratoxylum
sumatranum, aphrodisiac, in vitro, corpus cavernosum, vasodilation
Penulis: Sjarif Ismail, Meiliati
Aminyoto
Kode Jurnal: jpfarmasidd180034
