Cardioprotective Potential of Ethanol Extract of Sonchus Arvensis L. Leaves on Isoproterenol-Induced Myocardial Infarction in Rat
Abstract: Sonchus arvensis L.
leaves has been used traditionally to treat various disease conditions to
descrease blood preasure and increase urine excretion. This study was designed
to evaluate cardioprotective potential of ethanol extract of S. arvensis leaves
on isoproterenol-induced myocardial infarction in Wistar rat. Male Wistar
albino rats were divided into three main groups: negative control (saline
only), positive control (isoproterenol only), and S. arvensis extract treated
groups. S. arvensis extract was administered in three doses; 50, 100, and 200
mg/kg b.w. p.o for 14 days. On day 13 and 14, isoproterenol (85 mg/kg bw) was
given intraperitoneally to positive control and extract treated groups.The parameters
studied were cardiac biomarker enzymes which were Creatine Kinase (CK), Dehydrogenase
(LDH). The results showed that S. arvensis at dose of 50 mg/kg b.w. could
signifi cantly(P<0.05) reduce the level of CK, CK-MB, AST, ALT, and LDH in
myocardial infarcted rats comparedto positive control. The increase of the dose
of S. arvensis extract was not followed by an increase of its cardioprotective
activity. In conclusion, Sonchus arvensis L. leaves extract at dose of 50 mg/kg
b.w. haspotential to be developed as cardioprotective drug.
Keywords: Sonchus arvensis L.,
isoproterenol, myocardial infarction, cardioprotective drug
Penulis: NENG FISHERI KURNIATI,
ELIN YULINAH SUKANDAR, RIAN PARDILAH, NOVA SULISKA, DHYAN KUSUMA AYUNINGTYAS
Kode Jurnal: jpfarmasidd180044
