DEVELOPMENT AND EVALUATION OF CONTROLLED RELEASE FORMULATION OF LAMIVUDINE BASED ON MICROPOROUS OSMOTIC TABLET TECHNOLOGY USING FRUCTOSE AS OSMOGEN
Abstract: The present study
was undertaken to develop controlled release osmotic pump tablets of lamivudine
a nucleoside reverse transcriptase inhibitor for the treatment of acquired
immune deficiency syndrome (AIDS).The tablets were prepared by wet granulation
method using controlled release polymer hydroxyl propyl methyl cellulose
(HPMCE5 LV), MCC as diluent, starch as binder and fructose as osmogen. The
coating solution of core tablets were prepared by using cellulose acetate,poly
ethylene glycol 400,600,4000,6000 and acetone to quantity sufficient with
sorbitol for different batches. The prepared tablets were evaluated for pre
compression parameters, post compression parameters, in vitro drug release
study and scanning electron microscopy study. Among the prepared formulations
LF4 batch show 97.78% drug release in 12hrs.The in vitro release kinetics were
analyzed for different batches by different pharmacokinetic models such as zero
order, first order,Higuchi,Korsmeyer Peppas and Hixon Crowell model. Short term
stability study at 40±2ºC/75±5% RH for three months on the best formulation was
performed showing no significant changes in thickness, hardness, friability,
drug content and in vitro drug release.
Keywords: AIDS; wet
granulation; in vitro drug release; stability study
Author: Chinmaya Keshari
Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar
Journal Code: jpfarmasigg170021
