EFEK ANTIINFLAMASI EKSTRAK ETANOL DAUN KAMBOJA (Plumeria rubra L.) PADA TIKUS PUTIH (Rattus norvegicus)
Abstrak: Inflammation is a
body protective response against tissue injury which can be characterizet by
the formation of edema. Frangipani Leaves contain flavanoids, saponins and
alkaloids. The flavanoid compound is considered to have a useful effect for
healing edema. This research aimed to examine the effects of anti-inflamatory
and determined the dose of ethanol extract of the frangipani leaves(Plumeria
rubra L.) as an anti-inflammatory in the
rat. The test of anti-inflammatory effect was done by using the Rat Hind Paw
Edema method in which test animals it used 15 rats divided into 5 groups:
groups I (negative control) was given
Na.CMC 1% w/v, group II (positive control) was given diclofenac sodium, group
III, IV and V were given the ethanol extract of the frangipani leaves
successive doses of 166,6mg/kgBW, 222,2 mg/kgBW, and 277,7 mg/kgBW, all groups
were orally administered. The tested animals were induced carrageenan 1% w/v in
intraplantar 0,5 mL and were meansured their foot edema volume before performed
before induction as the intial volume (Vo), after induction, and 1 hour after
the administration of the dosage form for 5 hours with the intervals of 1 hours
using the pletismometer. The research result data were proccessed statistically
using on-wey anova. Based of the data analysis showed that the ethanol extract
of the frangipani leaves have the activity as the anti-inflammatory and
statistically, the assay extract group showed the result not significantly
different (p>0,05) against the diclofenac sodium group and a dose of
277,7mg/kgBB possessed the best activity compared to a dose of 166,6mg/kgBB and
222,2mg/kgBB
Kata Kunci: Anti-inflammatory,
Plumeria rubra L., Frangipani leaves, Diclofenacsodium
Penulis: Safriani Rahman,
Aulia Wati, Ema Sukmawati
Kode Jurnal: jpfarmasidd180148
