Efek Ekstrak Etanol Daun Gendola Merah (Basella alba L.) terhadap Kadar Kreatinin, Ureum dan Deskripsi Histologis Tubulus Ginjal Tikus Putih Jantan (Rattus norvegicus) Diabetes yang Diinduksi Streptozotocin
Abstract: The objective of
this study is to determine the effect and the effective dose of ethanolic
extract of Red Gendola (Basella alba L.) leaves on creatinine, urea and
description of histological tubular kidney of diabetic male rats induced by
streptozotocin. 30 male rats devided
into six groups : groups I, II, and III were the control groups and groups IV,
V, and VI were the experimental groups. Groups II, III, IV, V, and VI are given
induction of STZ 40 mg/kg BW in a single dose i.p on day 0. Normal control
group I and negatif control group II were given only Sodium-CMC 0,5%; positive
control group III was given glibenclamide 0,45 mg/kg BW; group IV, V, and VI
were given each extract at a dose of 100, 200, and 400 mg/kg BW in p.o every
day. The obtained data were analyzed using one way Anova test at the level of
95 % early followed by LSD Post Hoc Test, and the level of regeneration of
histological tubular kidney was observed by HE staining using Olympus BX-51
microscope with a scale of 100 μm and scoring data result of kidney tubular
damage levels were analyzed by Kruskal-Wallis test followed by Mann-Whitney
test to see the differences between treatments. The results showed that
ethanolic extract of red gendola with dose of 100 mg / kg BW give significant
effect to decrease the creatinine content and 200 mg / kg BW give effect of
decrease of ureum level of diabetic white male rats. Moreover, red gendola
ethanolic extract has also an effect on cell regeneration in renal tubules with
an effective dose of 400 mg /kg BW on diabetic male rats.
Keywords: Red gendola leaf, creatinine,
urea, histologis, tubular kidney
Penulis: Joni Tandi, Ayu
Wulandari, Asrifa Asrifa
Kode Jurnal: jpfarmasidd170577
