EFEK HEPATOPROTEKTOR EKSTRAK ETANOL DAUN JOHAR (Cassia siamea LAMK.) PADA TIKUS (Rattus norvegicus)
Abstrak: Johar leaf has been
empirically used as malaria and hepatitis medicine. This research aims to
determine hepatoprotective effect of ethanol extract of Johar leaves (Cassia
siamea Lamk.) of rats liver. This
research used 15 tested rats divided into 5 groups, group I was given
Na.CMC 1% (negative control), group II ethanolic extract of Johar leaves of 50 mg/kgBB,
group III ethanolic extract of Johar leaves of 250 mg/kgBB, group IV ethanolic
extract of Johar leaves of 500 mg/kgBB, and group V as a comparison given
suspension curliv® of 42,86 mg/kgBB. Giving suspension curliv® was orally done
once a day for 7 days. On the 8th day, the experimental rats were given
paracetamol suspension dosage of 2,5 g/kgBB. Measurements of SGPT content was
done before therapy (normal), after therapy, and after administration of
paracetamol. The results showed that the ethanolic extract of Johar leaves with
the dose of 50; 250; 500 mg/kgBB have a hepatoprotective effect and dose is 500
mg/kgBB which was not statistically significantly different from curliv®.
Kata Kunci: Hepatoprotective,
johar leaf, SGPT.
Penulis: Safriani Rahman,
Rachmat Kosman, Andi Cassia Siamea
Kode Jurnal: jpfarmasidd170412
