EFEK SENYAWA BIOAKTIF KAYU MANIS Cinnamomum burmanii NEES EX.BL.) TERHADAP DIABETES MELITUS: KAJIAN PUSTAKA
Abstrak: Diabetes Mellitus
(DM) is a chronic disorder of carbohydrate metabolism (glucose) in the body and
its prevalence is getting higher. Until 2015, 10 million cases of DM found in
Indonesia and allegedly ever increasing. Type II DM is the most common types of
DM in the world and its characterized by insulin resistance and β cell
damage. Due to the serious side effects
caused when taking chemical antidabetes drugs, herbal medicine searches from
natural materials continue to be done. Various spesieces of cinnamon plants
have been studied and known to have antidiabetic activity. One of them is
Cinnamomum burmanii which is found in Indonesia. Among the spesieces of
cinnamon have the same health benefits including antidiabetes, antimicrobial,
anti-fungal, antiviral, antioxidant, antitumor etc. Although the antidiabetic
mechanism of cinnamon is still debated, it is thought that cinnamon affects
several insulin signaling pathways, among others, in insulin receptors, glucose
transporter 4 (GLUT 4), glucose transporter-1 (GLUT 1), peroxisome proliferator
activator receptor (PPAR), α activity glucosidase etc. This activity is caused
of the bioactive compounds it contains. The main compounds that have
hypoglycemic activity are Methylhidroxy Calcone Polymer (MHCP), sinamaldehyde,
and polymer pro-ayanine type-A polymers or proanthocyanidin.
Keywords: Diabetes melitus, C.
burmanii, insulin resistence, β cell damage, bioactive compound
Penulis: Emilda
Kode Jurnal: jpfarmasidd180139
