EFEKTIVITAS ANTIHIPERGLIKEMIA TABLET CAMPURAN EKSTRAK DAUN PEPAYA DAN DAUN SALAM PADA TIKUS Sprague dawley
ABSTRACT: Plants which have a
potential effect as antihyperglycemic are papaya leaf and bay leaf. Papaya leaf
and bay leaf have a bioactive flavonoid component, which was suggested to have
reduction effect on blood glucose. The purpose of this research was to examine
the effectiveness of papaya leaf and bay leaf extract, which have been formulated
in tablet form to decrease blood glucose level on diabetic Sprague dawley rats
induced by alloxan. Twenty male rats were divided into four groups, Each group
consists of five rats, namely group I as a positive control(metformin 12.6
mg/200g BW), group II (oral tablet 1.282 mg/200g BW), group III (oral tablet
2.564 mg/200g BW) as extract treatment group, and group IV as negative control.
The treatment was carried out for 28 days. The result of this research showed
that tablet of papaya leaf and bay leaf extract can be used as
antihyperglycemic with the most effective dose was 2.564 mg/200g BB (group III)
and the treatment for twelve days.
Keywords: Antihyperglycemic,
Papaya leaf, bay leaf, tablet
Penulis: Erni Rustian1, Min
Rachminiwati, Lia Suryani
Kode Jurnal: jpfarmasidd170406
