Effect of Carrageenan as Gelling Agent on Tocopherol Acetate Emulgels
Abstrak: Vitamin E (Tocopherol
acetate) is used in both oral and topical dosage. The aim of
the research was to study
different concentration of Carrageenan, as gelling agent in Tocopherol
acetate Emulgels. This experimental
study was initiated by emulgel formulation using different concentration of
carrageenan as gelling agent, as much as 0,5% (F1), 0,75% (F2), 0,85% (F3),
0,95 % (F4), 1% (F5), 1,125% (F6), 1,25% (F7), 1,5% (F8) and 2% (F9). Tween 20 and Span 20 were used as emulsifiers
(1 and 1,5 %), Liquid paraffin as oily
phase (7,5%), Propylen glycol as humectant (10%), propyl and methyl paraben as
antimicrobial preservative (0,01% and 0,03%). The physical investigation of
emulgel were included pH, spreading test, viscosity and freeze thawtest. The
results for promising formula F5 showed that physical parameters of emulgels
were in the range of requirement for topical dosage form.
Keywords: Tocopherol acetate (Vitamin E), emulgels, carrageenan
Penulis: Meiti Rosmiati,
Marline Abdassah, Anis Yohana Chaerunisaa
Kode Jurnal: jpfarmasidd180219
