EFFECT OF Curcuma xanthorrhiza Roxb. EXTRACT ON TNF α CONCENTRATION AND DEPRESSION’S SCORE IN PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS
ABSTRACT: Systemic Lupus
Erythemathosus is an autoimmune,inflammatory, chronic disorder characterized by
multiorgan system involvement. Depression and anxiety are frequent complaints
among patients with lupus erythematosus, so antidepressive treatment should be
an important element of thetherapy of patients with lupus erythematosus.
Research into curcumin’s potential as a treatment for depression is still in
its infancy, although several potential antidepressant mechanisms of action
have been identified. 4-weeks double-blind, placebocontrolled clinical trial
was conducted in 14 SLE patients (10 as the treatment group and 4 as a control
group) The BDI (Beck Depression Inventory) score was calculated and TNF α concentration
was measured in the serum subjects before and after treatment. Correlation
between TNF α concentration and BDI was assessed. After 4 weeks treatment, the
TNF α concentration from subjects in the treatment group was significantly
lower than before (p<0.001) but the BDI score were not significantly lower
than before (p=0.059). The TNF α concentration and BDI score showed a positive
correlation, p = 0.024. This study demonstrates that Curcuma xanthorrhiza Roxbextract
can decrease serum TNF α concentration and reduce clinically symptoms of
depression in SLE patients.
Keywords: Curcuma xanthorrhiza
Roxb. Extract, Systemic Lupus Erythematosus, Tumor Necrosis Factor α, Beck
Depression Inventory
Author: Maria Caecilia N.
Setiawati, Zullies Ikawati, Kertia Nyoman
Journal Code: jpfarmasigg170003
