Effect of Drying Technique on Physical Quality and AntiInflammatory Activity of Wild Betel Leaves (Piper Sarmentosum Roxb. Ex Hunter) Extract
Abstract: Wild betel leaves
(Piper sarmentosum Roxb. ex. Hunter) contain fl avonoids and alkaloidsthat have
anti-infl ammatory activity. Processing thick extract into a dry extract is
required to determinethe appropriate dose and increase the homogeneity. The
purpose of tahhis study was to determine theeff ect of drying method to physical
properties of dried powder and its antiinfl ammatory activity. Thickextract was
dried using maltodextrin and lactose as adsorbents with concentrations of
extract-adsorbent ratio 1 : 1, 1 : 2 and 1 : 3. Method of drying were freeze
drying and adsorbent. The evaluation resultsbased on organoleptic dried powder,
water content and fl ow properties. The water content of driedpowder which is
dried by freeze drying is smaller than that of the adsorbent. Organoleptic and
fl owproperties of freeze dried powder results were also better. The best dried
extract in each method testedits anti-infl ammatory activity using Bovine Serum
Albumine (BSA) denaturation methods. The results showed that the anti-infl
ammatory activity of dried extract of freeze drying (extract - maltodextrin1 :
3) had higher activity with IC50 551.79 ppm compared to dried extract with
adsorbent (extract - maltodextrin 1 : 3) with IC50 of 598.30 ppm.
Keywords: Piper sarmentosum
Roxb. ex Hunter, anti-infl ammatory activity, freeze drying, adsorbent
Penulis: FAHLENI, SYARIFAH
RAMADHANI, YUSLIA NOVIANI.
Kode Jurnal: jpfarmasidd180046
