Effect Test Stimulant of Curcuma Rhizome Infusion (Curcuma xanthorrhiza Roxb.) On Male Mice Swiss Strain
Abstract: The used of plants
efficacious as medicines in the prevention of health problems had been known
for a long time the Indonesian people. The utilization of plants as medicine
was based on the experience passeddown from generation to generation. The used
of traditional medicines relatively favored by the people,the underlying factor
are traditional medicines have less side effects than the modern medicines if
usedappropriately. Curcuma (Curcuma xanthorrhiza Roxb.) used as refreshment
which had stimulant effect..Stimulant was a substance that can stimulated the
central nervous system which can speed up the processes in the body and
minimize fatigue. Need to research the effects of stimulant infusion of curcuma
rhizome.The research was conducted experimental methods pre-test and post-test.
Twenty-five male mice Swissstrain used as experimental animals, which are
divided into five groups, positive control (caffeine 100mg /kg BW), negative
control (distilled water 0,5ml /20g BW), infusion of curcuma dose I (2.5 g/ kg
BW), doseII (5g / kg BW), and dose III (10g / kg BW) respectively. Animal
experiments tested using methods NatatoryExhaustion and treated with oral
route. The effects of stimulant tired was calculated the time differencebefore
and after treatment. The data obtained were analyzed non-parametric statistical
tests, it’s KruskalWallis and Mann Whitney with a 95% confidence level. Infuse
curcuma rhizome had the stimulant effect,the effect was obtained by increased
the dose. At doses of 2.5 g / kg BW, 5g / kg BW, and 10 g / kg BW wasprovide a
stimulant effect respectively by 2.82 minutes, 3.71 minutes and 4.94 minutes.
Stimulant effect doseII and III had a greater effect than the positive control
(p<0,05), the dose I had similar effect compare with control positive
(p>0,05).
Keywords: infusion of curcuma
rhizome, stimulant effect, Natatory Exhaustion, male mice
Penulis: Neni Lugki Nian Tary,
Tanti Azizah Sujono
Kode Jurnal: jpfarmasidd170436
