Formulasi dan Evaluasi Granul Gastroretentive Mukoadhesif Amoksisilin
Abstrak: Amoxicillin is a
semisynthetic antibiotic, belonging to the β-Lactam family, which is effective
for bacterial infection treatment, especially for Helicobacter pylori
infection. In this research, Amoxicillin was formulated as mucoadhesive
granules dosage form to improve their effectivenesses by increasing the
residence time of dosage form in the stomach. Mucoadhesive granules were
prepared by wet granulation method in ten formulas using HidroxypropylMethyl
cellulose, Methyl cellulose and Ethyl cellulose as mucoadhesive polymers.
Granules were evaluated for moisture content, flow rate, angle of repose,
density, mucoadhesive strength with wash off test, and dissolution. The results
of this researchshowed that formula IB with 50% HPMC has best mucoadhesive
strength with percentage of mucoadhesion 20% in 90 minutes of wash off test,
and also formula IB is slowest formula in releasing of drug, with percentage of
drug released is 55,76% in 15 minutes and 104,01% in 180 minutes.
KATA KUNCI: Granule.,
Gastroretentive., Mucoadhesive., Amoxicillin
Penulis: Hamsinah, Jufri, Ermina Pakki
Kode Jurnal: jpfarmasidd160690
