Formulasi Dan Evaluasi Stabilitas Fisik Suspensi Ibuprofen Menggunakan Kombinasi Polimer Serbuk Gom Arab Dan Natrium Karboksimetilselulosa
Abstrak: The research about
formulation and evaluation of physical stability of ibuprofen suspension using
arabic gom and natrium
carboxymethylcelulose as suspending agent had been done. Concentration of
arabic gom and natrium
carboxymethylcelulose were 2.5 : 0.25, 5 : 0.5, 2.5 : 0.75 and 5 : 1 % for F1,
F2, F3 and F4 respectinely. Evaluation of physical stability had been done for 8 weeks, ie organoleptic, density,
viscosity, volume of sedimentation, redispresion, pH, freeze thaw cycling,
crystal growth and particle size distribution. Concentration of arabic gom and
natrium carboxymethylcelulose had been influenced the physical stability of
suspension.
Kata Kunci: Ibuprofen;
Suspension; Polimer; Pulvis Gummi Arabici; Natrium Carboxymethylcelulose
Penulis: Rina Wahyuni, Syofyan,
Septa Yunalti
Kode Jurnal: jpfarmasidd170362
