FORMULASI EKSTRAK ETANOL GAMBIR (Uncaria gambir Roxb.) DALAM BEDAK ANTI JERAWAT
Abstract: Acne occurs due to
blockage of pilosebaseus (oil glands) and inflammation causing by
Propionibacterium acne, Staphylococcus epidermidis and Staphylococcus aureus.
The purpose of the study was to test the antibacterial activity of gambir
(Uncaria gambier Roxb.) ethanol extract toward Staphylococcus epidermidis and
to formulate gambir ethanol extract into a loose powder dosage form that meets
the standards of physical powder quality. Gambir was macerated with 95%
ethanol. Activity of gambir ethanol extract against Staphylococcus epidermidis
was tested by diffusion method using varying concentrations 3%, 6% and 9% of
gambir etanol extract. Afterward, gambir ethanol extract formulated into
powder. Analyze of powder physical properties including organoleptic test,
homogeneity and particle size distribution. The results showed gambirethanol
extract 3%, 6%, 9% has inhibition zone diameter 3.6 mm, 4.2 mm, and 6.8 mm respectively.
Gambir ethanol extract powder has a homogeneous, fine size with a light brown
color and a distinctive gambir aroma. The average particle size of the powder
is 236.17 μm
Keywords: Gambir (Uncaria
gambir Roxb.), loose powder, diffusion method, Staphylococcus epidermidis
Penulis: Husnul Warnida, Agustiani
Masliyana, Sapri
Kode Jurnal: jpfarmasidd160448
