FORMULASI ORALLY DISINTERGRATING TABLET (ODT) EKSTRAK ETANOL DAUN KEMANGI (Ocimum americanum L.) DENGAN VARIASI KONSENTRASI EXPLOTAB®
Abstract: Bad breath is
usually caused by bacteria and leftovers in the mouth. Utilization of natural
ingredients that can be used to overcome the problem of bad breath one of them
by using basil leaves (Ocimum americanum L.), which has activity as an
antibacterial. The development of the preparations was done on basil leaves to
overcome bad breath is by formulating the basil leaves ethanol extract into the
Orally Disintegrating Tablet (ODT) preparation. The purpose of this study was
to investigate the effect of explotab® concentration variations on the physical
properties of ODT and to determine the best of concentrations of Explotab® that
fulfill the physical properties of ODT. The type of research conducted was an
experimental study. Research object was basil leaves ethanol extract formulated
into ODT with Explotab® 2% w/b, 4% w/w, 6% w/b and 8% w/w variation. Physical
evaluations test then conducted including : the uniformity of weight
evaluation, the hardness test, the friability test, and the dissolved time. The
results showed that the explotab® concentration variations had an effect on the
physical properties of tablets and the formula with the Explotab® 8% b/b
concentration was the best formula that could produce the best ODT tablet with
physical properties.
Keywords: Basil leaves (Ocimum americanum L.), Explotab®, Orally
Disintegrating Tablet (ODT)
Penulis: Yulistia Budianti Soemarie, Hayatus Sa'adah, Tri
Marginingsih
Kode Jurnal: jpfarmasidd180026
