FORMULASI SEDIAAN GEL DISPERSI PADAT IBUPROFEN : STUDI GELLING AGENT DAN SENYAWA PENINGKAT PENETRASI
Abstract: This study aims to
determine the effect of using gelling agent and chemical penetration enhancer
on the solid dispersion Ibuprofen gel in increasing the transdermal drug
penetration. Inhibition of the COX-1 enzyme caused by ibuprofen in oral
administration can cause side effects of gastrointestinal disorders, dyspepsia,
diarrhea, upper gastrointestinal infections, nausea and bloating, resulting in
a topical route to reduce side effects. The gel is prepared using hydroxy
propyl methyl cellulose (HPMC) and carbopol® as gelling agents, and also
propylene glycol and glycerin as chemical penetration enhancer compounds. The
gel evaluation are viscosity, pH, spreadability and penetration flux rate. The
value of the formula 3 penetration flux is 1.5383 ± 0.029 ug / cm2.minute, the
formula 1 is 1.403 ± 0.055 ug / cm2. minute, the formula 2 is 0.756 ± 0.071 ug
/ cm2 minute, while the formula 4 is 0.5404 ± 0.106 ug / Cm2. minute. The
amount of gelling agent concentration and chemical penetration enhancer
compound effect on the value of the flux penetration
Keywords: Gel, Ibuprofen,
transdermal, gelling agent, chemical penetration enhancer
Penulis: Dwi Nurahmanto, Ifa
Rosi Mahrifah, Rani Firda Nur Imaniah Azis, Viddy Agustian Rosyidi
Kode Jurnal: jpfarmasidd170134
