FORMULATION AND EVALUATION OF ORAL SUSTAINED IN SITU GELLING SYSTEM OF ROXATIDINE
Abstract: Gel dosage forms are
successfully used as drug delivery systems to control drug release and protect
the medicaments from a hostile environment. The main objective of this present
work is to formulate and evaluate in situ gels of roxatidine for the treatment
of peptic ulcer. This system utilizes polymers that exhibit sol-to-gel phase
transition due to change in specific physico-chemical parameters. In the
present work in situ gels have been developed by using gellan gum and sodium
alginate based on the concept of ion activated systems. Sol-to-gel
transformation occurred in the presence of monovalent/divalent cations.
Formulations were evaluated for clarity, drug content, in vitro gelling
capacity, determination of pH, in situ release study, viscosity, gel strength,
ex vivo gelation and stability study. All the results found to be satisfactory.
Experimental part showed that viscosity of sols and gel strength was increased
with increase in the concentration of polymers, also drug release gets
sustaining. The formulations were therapeutically efficacious, sterile and
provided sustained release of the drug over a period of time. These results
demonstrated that the developed system is an alternative to conventional drug
delivery systems and can improve patient compliance.
Key words: In situ gels,
Roxatidine, Peptic ulcer
Author: Mohammed Gulzar Ahmed,
Chirag Kapoor, Sanjana A
Journal Code: jpfarmasigg170018
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